Anti-Dyslipidemia Effect of Ethanol Extract of Passiflora foetida on Dextrose Induced Diabetic Rats

Ravi Babu Birudu1, M. Jagadish Naik2*, Janardhan M3

1Department of Biotechnology, Acharya Nagarjuna University, Guntur- 522510, A.P, India

2Department of Zoology & Aquaculture, Acharya Nagarjuna University, Guntur- 522510, A.P, India

3,Department of Pharmacology, Nimra College of Pharmacy, Jupudi, Vijayawada- 521456, A.P, India

Received: 28-Sep-2015 , Accepted: 22-Oct-2015

Keywords: Dextrose, Diabetes, Dyslipidemia, Silver nanoparticles, Passiflora foetida

DOI: http://dx.doi.org/10.20510/ukjpb/4/i1/87840

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Abstract

Dyslipidemia leads to cardiovascular disease (CVD) and it is determined by elevation of plasma concentration of lipoproteins. Diabetes is a chronic disorder and it is controlled by different allopathic and Ayurvedic formulation. The synthetic drugs include sulfonyl ureas, biguanides, metformin HCl, DPP-4 inhibitors etc. The folk medicine is practiced by local people. The people use herbal medicine to control and treat the various types of diseases. In India, tribal people used different types of medicinal plants to control the diabetes. In present study ethanol extracts of Passiflora foetida leaves were evaluated for anti-dyslipidemia activity in dextrose induced diabetic rats. The ethanol extracts of P. foetida were administered at the doses of 100 mg/kg body weight, 250 mg/kg body weight and 500 mg/kg body weight to the dextrose induced diabetic rats. The silver nanoparticles were prepared by the reaction of 1 mM silver nitrate and 5% leaf extract of P. foetida. The antidyslipidemia activity of ethanol extracts was compared with standard drugs Glipizide, Sitagliptin and Vildagliptin. The standard drugs normally decreased the lipid parameters in diabetic rats. The ethanol extract at the dose of 500 mg/kg body weight showed significant lowering effect on dextrose induced diabetic rats. The total cholesterol, triglycerides, low-density lipoprotein (LDL) and very low density lipoprotein (VLDL) were decreased by ethanol extract and standard drugs. Additionally the ethanol extract reduced the HDL level in treated animals. The silver nanoparticles produce lower effect on lipid profile.